Targeting LDL Cholesterol: Beyond Absolute Goals Toward Personalized Risk Academic Article uri icon


  • Abstract Purpose of Review The aim of this study was to review and assess the evidence for low-density lipoprotein cholesterol (LDL-C) treatment goals as presented in current guidelines for primary and secondary prevention of cardiovascular disease. Recent Findings Different sets of guidelines and clinical studies for secondary prevention have centered on lower absolute LDL-C targets [< 70 mg/dL (< 1.8 mmol/L)], greater percent reductions of LDL- C (≥ 50%), or more intense treatment to achieve greater reductions in cardiovascular risk. Population-based risk models serve as the basis for statin initiation in primary prevention. Reviews of current population risk models for primary prevention show moderate ability to discriminate [with c-statistics ranging from 0.67 to 0.77 (95% CIs from 0.62 to 0.83) for men and women] with poor calibration and overestimation of risk. Summary Individual clinical …

publication date

  • January 1, 2017