Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1 Academic Article uri icon


  • RESULTS Generation of Ncr1gfp/gfp mice We initially maintained the Ncr1gfp/gfp mice on the 129/Sv strain because gene targeting was done in R1 embryonic stem cells (Supplementary Figure 1 online), which are of the 129/Sv background. In addition, the DAP12 adaptor protein, which transduces signals from Ly49-activating receptors, is impaired in 129/Sv mice30. As NCR1 signals via the T cell receptor-z chain, its activity would not be impaired in 129/Sv mice. Therefore, the 129/Sv background would allow a distinct …

publication date

  • January 1, 2006