68. Interhemispheric Paired Associative Stimulation of the Prefrontal Cortex Induces Acute Cognitive and Electrophysiological Alterations Academic Article uri icon


  • Background Interhemispheric paired associative stimulation (PAS) is an emerging protocol for TMS that can potentially target connectivity across hemispheres. Yet, most studies have thus far been limited to the motor cortex. We set out to evaluate potential electrophysiological and behavioral modifications following PAS between the right and left prefrontal cortex (PFC) that are dependent on the direction in which PAS is administered, ie, which hemisphere is stimulated first. Methods Twenty seven subjects were recruited for a three session, sham-controlled crossover study, receiving left to right PAS (LR-PAS), right to left PAS (RL-PAS) and sham during different weeks. The protocol consisted of 210 pulse pairs with an ISI of 8ms. Subjects performed the emotional Stroop task, assessed by measuring attentional bias, and brain activity was recorded with EEG prior to and …

publication date

  • January 1, 2017