Apoptosis of Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma revisited Academic Article uri icon

abstract

  • Department of Microbiology-Immunology, Faculty of Health Sciences,Ben Gurion University, Beer-Sheva, IsraelBenharroch D, Einav I, Feldman A, Levy A, Ariad S, Gopas J. Apoptosis of Hodgkin–Reed–Sternbergcells in classical Hodgkin lymphoma revisited. APMIS 2010; 118: 339–45.We scrutinized the role of apoptosis of the Hodgkin–Reed–Sternberg (HRS) cells in classical Hodgkinlymphoma (cHL) and critically reviewed its features in the light of conflicting evidence. In this study,we found that tumor cells in this neoplasm showed inhibition of apoptosis in 55% of the 217 cHL casesonly. It is also suggested that the two factors considered responsible for apoptosis inhibition in HRScells, nuclear factor-jB and the latent membrane protein-1 of the Epstein–Barr virus, do not correlatewith apoptosis inhibition, in contrast with the findings in the consensual pathogenetic scheme. Themost significant association of HRS cell apoptosis was with p53, the negative expression of whichrelated with a high apoptotic index (p = 0.001). These findings support our contention that the role ofapoptosis in the HRS cells of Hodgkin lymphoma has not been completely elucidated and is at variancewith that in the consensus.Key words: Hodgkin lymphoma; apoptotic index; NF-jB; measles virus.D. Benharroch, Department of Pathology, Soroka University Medical Center, PO Box 151, Beer-Sheva84101, Israel. e-mail: benaroch@bgu.ac.il

publication date

  • January 1, 2010

published in