- Abstract We explore the quark mass effects on inclusive hadron production in proton- nucleus collisions at high energies. We consider two processes. First, we compute the single inclusive cross section for production of hadrons with open heavy flavor in the proton forward direction at leading order. Next, in the same kinematics, we calculate the heavy- quark contribution to single inclusive production of light or unidentified hadrons at next-to- leading order. For both studies, we exploit the hybrid formalism; that is, the collinear factorization on the proton side while high-density and high-energy effects are resummed on the side of the nucleus.