499: Maternal hypothyroidism and the risk for future infectious morbidities of the offspring Academic Article uri icon


  • Objective Maternal hypothyroidism during pregnancy is associated with reduced cognitive function of the offspring. Recently, a possible intrauterine immunological imprinting in pregnancies complicated by hypothyroidism was suggested. We aimed to assess whether exposure to hypothyroidism during pregnancy increases the risk of long-term infectious morbidity in the offspring. Study Design A retrospective population-based cohort study compared long-term infectious morbidity of offspring following pregnancies exposed and unexposed to maternal hypothyroidism. Deliveries occurred in a regional tertiary medical center between the years 1991-2014. Congenital malformations were excluded from the study. A survival curve and a Cox multivariate model were used to assess the association. Results During the study period 217,910 deliveries met the inclusion criteria; 1.1% of …

publication date

  • January 1, 2018