Low-threshold calcium electrogenesis in neocortical neurons Academic Article uri icon


  • Abstract In slices of parietal neocortex, evidence was obtained for the existence of a low-threshold Ca 2+ conductance in most neurons. This conductance became apparent when resting membrane potential was held below −60 mV by continuously injected, depolarizing current. Under these conditions, brief hyperpolarizing pulses were followed by generation of tetrodotoxin (TTX)-resistent, Mn 2+ -sensitive, low-threshold spikes. The results suggest that in neocortex, as in many subcortical structures, low-threshold Ca current may be responsible for burst generation in some neurons.

publication date

  • January 1, 1987