Induced Color Change of Conjugated Polymeric Vesicles by Interfacial Catalysis of Phospholipase A2 Academic Article uri icon


  • A blue to red color change is induced on addition of phospholipase A2 to modified PDA vesicles 1 (PDA= polydiacetylene). This bathochromic transition results from chemical modification of the vesicles by hydrolysis of the enzyme substrate embedded in the PDA matrix. Addition of a known phospholipase inhibitor or removal of Ca2+ ions suppresses the color change, which suggests the potential for applications in high‐throughput screening assays.

publication date

  • January 1, 1999