Inositol-induced mania? Academic Article uri icon


  • Mr. A, a 24-year-old man with no family history of affective illness, was previously given numerous antidepressant medications for treatment of recurrent major depression. He refused to undergo ECT, and various drug combinations were tried but resulted in only partial improvement. On a regimen of phenelzine, 45 mg/day, and inositol, 15 g/day, he experienced a 4-week remission but then became depressed again. Without consulting with his doctors, he then raised his inositol dose to 27 g/day. Seven days later, hypomania developed that was manifested by hyperactivity, pressure of speech, intrusiveness, insomnia, and exaggerated sexual activity. The inositol dose was lowered to 20 g/day, and the hypomania remitted in 4 days.Ms. B, a 31-year-old woman with a family history of bipolar disorder, was diagnosed as suffering from recurrent major depression. During an episode …

publication date

  • January 1, 1996