Metallothioneins in neurodegeneration Academic Article uri icon


  • ABSTRACT Metallothioneins are ubiquitous low molecular weight proteins characterized by an abundance of the thiol-containing amino acid, cysteine. Metallothionein 1 and metallothionein II. the most widely expressed isoforms. are co-ordinately regulated in all mammalian tissues, while a third variant, metallothionein III. is predominantly expressed in zinc-containing neurons and absent from non-neural tissue. Metallothionein proteins have been implicated as regulators of gene expression in homeostatic control of cellular …

publication date

  • January 1, 2003