Mechanistic studies of ultrasonically enhanced transdermal drug delivery Academic Article uri icon

abstract

  • The transdermal route of drug delivery offers a noninvasive and painless alternative to more traditional routes such as injections. However, its applicability is limited to only a handful of drugs due to the low permeability of the skin. It has been demonstrated that low‐frequency ultrasound significantly enhances transdermal transport of a variety of drugs (sonophoresis). There is strong experimental evidence to suggest that cavitation plays a key role in this enhancement, although it is not clear which cavitational effects are primarily responsible for the transport. Cavitation can affect transdermal transport in at least two ways: It can induce changes in skin structure, creating pathways or channels for molecules to diffuse across and/or it can induce convective transport across the skin. An experimental system has been developed to assess contributions due to each of these phenomena individually …

publication date

  • May 1, 1998