Anti-inflammatory effect of a Nuphar lutea partially purified leaf extract in murine models of septic shock Academic Article uri icon


  • Ethnopharmacological relevance Various plant organs of Nuphar lutea (L.) SM.(Nymphaeaceae) are used in traditional medicine for the treatment of arthritis, fever, aches, pains and inflammation. The main purpose of this study was to determine the anti- inflammatory effect of Nuphar lutea leaf extract (NUP) in two septic shock models:(1) Survival of mice challenged with a lethal dose of LPS, determination of pro-inflammatory and anti-inflammatory cytokines in serum, as well as in peritoneal macrophages in cell culture.(2) The effect of NUP in a murine model of fecal-induced peritonitis. Materials and methods NUP pre-treatment partially protected mice in two models of acute septic shock. We concluded that NUP is anti-inflammatory by inhibiting the NF-κB pathway, modulating cytokine production and ERK phosphorylation. Results A significant average survival rate …

publication date

  • January 1, 2015