Keeping those telomeres short! an innovative intratumoral long-term drug delivery system Academic Article uri icon

abstract

  • Background Telomerase activation and an alternative lengthening of telomeres (ALT) mechanism are two telomere-lengthening cancer cell survival mechanisms elicited by both chemo-and/or radiotherapy. Telomere lengthening interferes with cell lethality and results in the immortalization of cancer cells. To counteract these mechanisms, we developed a drug delivery system (DDS) consisting of a polymeric implant that is inserted directly into tumors. The DDS releases, continuously and gradually, a cationic porphyrin (PdTMPyP4) for> 30 days after a single application, and inhibits telomerase activation. Methods The PdTMPyP4 porphyrin is incorporated into a poly (co-glycolic lactic) acid (PLGA) polymer, solidified and cut into small rods. PdTMPyP4 release from the rods was measured spectrophotometrically over time. Uptake of Pd in the DNA of in L428 Hodgkins lymphoma cells was measured …

publication date

  • January 1, 2014