Prospective epidemiologic surveillance of invasive pneumococcal disease and pneumonia in children in San Jose, Costa Rica Academic Article uri icon


  • Background and aim: Streptococcus pneumoniae is globally the leading cause of vaccine- preventable death in children below 5 years of age. Methods: Between 2007 and 2009, a prospective, population-based surveillance was conducted in children aged 28 days to 36 months in San José, Costa Rica. Incidence of invasive pneumococcal disease as well as clinically-and chest X ray-confirmed pneumonia were determined, as well as serotype distribution and antibiotic susceptibility. Results: 8801 subjects were enrolled (median age: 14.5 months). Invasive pneumococcal disease was detected in 25 children by isolation from cultures (22) or by PCR and a clinical picture consistent with invasive pneumococcal disease (3). For culture-positive only cases in children aged 28 days to< 36 months, the invasive pneumococcal disease incidence rate was 33.7/100,000 per year for years 1 …

publication date

  • January 1, 2012