Estimated glomerular filtration rate within the normal or mildly impaired range and incident cardiovascular disease Academic Article uri icon


  • Background The association between lower estimated glomerular filtration rate (eGFR) and incident cardiovascular disease is less clear within the normal or mildly impaired range. Methods Using the Chronic Kidney Disease EPIdemiology collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) eGFR formulas, we analyzed outpatients≥ 22 years old from 2004-2006 with 60 mL/min/1.73 m 2< eGFR< 130 mL/min/1.73 m 2, without prior cardiovascular disease, and with and without proteinuria. Results During a median follow-up of 96 months and> 10 million patient-years of follow-up, 103,506 and 104,315 cardiovascular events were recorded using CKD-EPI (n= 1,341,400, mean age 49.2 years, 42.6% male) and MDRD (n= 1,284,762, mean age 50.2 years, 43.4% male) formulas, respectively (incident event rates 4.4% and 4.6%, respectively). Adjusting for …

publication date

  • September 1, 2015