What intensity of deep repetitive transcranial magnetic stimulation is necessary to remit treatment resistant depression Academic Article uri icon


  • Background: dTMS for treatment resistant depression uses high frequency pulses to stimulate the prefrontal cortex at an intensity of 120% of the resting motor threshold (120MT). Is 120MT necessary to achieve remission or are lower intensities efficacious? Intensity and efficacy data from the active arm of the Brainsway multicenter clinical trial were analyzed. Methods: 101 active dTMS multicenter trial participants received 4 weeks of 5-a-week H1- coil dTMS. From treatment 3 and on subjects had to receive stimulation at 120% of MT. HDRS-21 scores up to week 5 and remission and response rates at week 5 were compared between patients who received adequate and lower dTMS doses (a protocol deviation). Results: Twelve patients received an average intensity< 118MT (mean±SD= 112.5%±4.0%) are considered the low dose (LD) group. Six of the LD patients had at least one HDRS-21 …

publication date

  • January 1, 2018