The Cholinergic Model for PTSD: From acute stress to PTSD, From Neuron to Network and Behavior Academic Article uri icon


  • Emotional stress is often followed by long-term changes in brain functions. In humans, such changes can be clinically diagnosed as post-traumatic stress disorder (PTSD), a mental condition characterized by re-experiencing of the event, avoidance, numbing of responsiveness and hyper-arousal. While the neurobiological mechanisms of PTSD are not known, accumulating clinical observations suggest that in most cases:(i) the acute traumatic event has a significant emotional impact on the individual and is perceived as “life …

publication date

  • October 6, 2009