Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Academic Article uri icon


  • Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder … Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol … The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal … The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder … Inositol is an isomer of glucose and a natural constituent of the normal human diet (1). Interest in inositol accelerated with the discovery of the …

publication date

  • January 1, 1995