B68 Chronic Mild Stress Induces Depressive Behaviors In Adult But Not Young Rats: Potential Role For Ampa Receptors Academic Article uri icon


  • Chronic mild stress (CMS) in adult animals is known to induce depressive-like behaviors, but the effects of CMS on young animals has not been studied. In this study we compared behavioral as well as neurochemical effects of 4 weeks of CMS on young and adult male rats. We have used a standard protocol of CMS periods of food and/or water deprivation, cage tilt, white noise and wet bedding. We performed automatic measures of spontaneous locomotor activity in the home cage, explorative behavior in an open field, the forced-swim test, preference for sweet solutions and sexual behavior tests. We have also compared expression of AMPA receptors within specific reward-related brain regions using immunohistochemistry. CMS in adult rats induced a significant decrease in sucrose preference. This effect was not observed in the young CMS rats. The adult CMS rats …

publication date

  • January 1, 2005