Effects of EAA Scavengers (Oxaloacetate and Pyruvate) after Head Injury Academic Article uri icon

abstract

  • Methods: With institutional approval, 72 male, Sprague-Dawley rats weighing 220–280 g were anesthetized with halothane for surgical preparation (scalp incision and arterial catheter placement) and randomly assigned to groups within one of two cohorts. In one cohort (n= 32) the groups were 1= sham operation+ no CHT, 2= CHT+ 0.9% saline, 3= CHT+ oxaloacetate sodium 1000 mcg/kg, and 4= CHT+ pyruvate 900 mcg/kg. In the second cohort (n= 40) the groups were 1= sham operation+ no CHT, 2= CHT+ 0.9% saline, 3= CHT+ glutamate 140 mg/kg, 4= CHT+ oxaloacetate+ glutamate, and 5= CHT+ pyruvate+ glutamate. CHT (impact energy of 0.5 J) was delivered over the left hemisphere. In all 9 groups neurological severity score (NSS, 25 point scale, 0= intact) was determined at 1 h. In the CHT groups, treatments (all as 1.5 ml) were given over 30 min after assessing NSS at …

publication date

  • October 1, 2004