Neurobiological concepts in schizophrenia and their association to traditional classifications Conference Paper uri icon


  • Methods: Results are presented from studies designed to assess first, integrity of sensory processing at the level of auditory and visual cortex and, second, effects of the NMDA agonist D-serine on sensory and cognitive function in schizophrenia. Integrity of sensory processing was assessed using a combination of event-related potential (ERP) and fMRI approaches. Patterns of dysfunction in schizophrenia were compared to those observed in animal models of NMDA impairment. D-Serine was administered as part of a PK/PD dose escalation study, at a dose of 60 mg/kg (approx. 4 g/d). Outcome measures included auditory and visual ERP, symptom and cognitive measures. Results: Patients with schizophrenia showed significant deficits in generation of both auditory and visual ERP. Deficits in auditory ERP were manifest as reduced activity of mismatch negativity (MMN) …

publication date

  • July 1, 2008