Bursts of high frequency repetitive transcranial magnetic stimulation suppress ongoing seizures and augment lorazepam efficacy in a rat kainate status epilepticus m... Academic Article uri icon

abstract

  • Background Status epilepticus (SE) is a condition of prolonged, and often drug-resistant, seizures. Successful pharmacologic SE treatment often leads to sedation and respiratory depression. A non-pharmacologic and non-sedating SE therapeutic thus remains an important unmet need. Repetitive transcranial magnetic stimulation (rTMS) is emerging as a means to suppress seizures, but has not been extensively studies in SE models. Methods We summarize two experiments using the rat intraperitoneal kainate (KA) under urethane anesthesia model. In both, EEG was collected continuously after KA injection. In the first, we tested whether high-frequency rTMS suppresses seizures. Rats were divided into three groups to receive (1) KA+ verum rTMS (10 bursts of 20 Hz, 30 sec ITI, 80% MO intensity, N= 9),(2) KA+ sham rTMS (N= 9) and (3) saline+ sham rTMS (N= 6). Next, we tested whether …

publication date

  • March 1, 2014