Brain self-protective scavenging of blood glutamate Academic Article uri icon

abstract

  • Background: High Glutamate (Glu) levels in brain interstitial and cerebrospinal fluids (ISF and CSF, respectively) are the hallmark of several neurodegenerative conditions. These conditions include acute brain insults such as traumatic brain injury, bacterial meningitis and stroke, or chronic insults such as glaucoma, amyotrophic lateral sclerosis or HIV dementia. Its removal is essential to prevent glutamate excitotoxicity that causes long lasting neurological deficits. Inherent brain protection is credited mainly to the presence, both on nerve terminals and on astrocytes, of members of a large family of Na+-dependent Glu transporters. Little attention has been given to the Glu transporters present on brain blood vessels. In this study we show the relationship between blood Glu concentration and brain Glu levels and the factors affecting them. Methods: Sprague-Dawley rats were subjected …

publication date

  • October 1, 2006