Electrochemical Whole-Cell Low Profile Biochips Academic Article uri icon


  • Various aspects of electrochemical whole-cell biosensing of genotoxicants were investigated with an electrochemically-based micro-fluidic whole-cell biosensor for water genotoxicity analysis [1], including bio-chip fabrication and performance, signal modeling, bio-material integration and characterization, and the effect of external electrical fields on the biosensing capabilities. The biosensor presented here is based on a “dip & measure” concept for portable, on-site mode of detection (Figure 1). The biosensor performance was evaluated on 3D electrodes manufactured by MEMS technology to enhance signal to noise ratio (Figure 2). The generated bio-electrochemical signal was modeled and resulted in good correlation of experimental results to the analytical representation of the generated current, and was followed by further characterization of physical aspects of the whole-cell …

publication date

  • July 8, 2010