Blood-brain barrier breakdown and blood-brain communication in neurological and psychiatric diseases Academic Article uri icon

abstract

  • More than a century ago, Paul Ehrlich demonstrated in a set of dye experiments the lack of permeability of intracerebral vessels to albumin-binding dyes and therefore postulated a barrier between blood and neuronal tissue. Indeed, transport across the blood-brain barrier (BBB) is tightly regulated by at least four different cells that comprise the brain microvasculature: the endothelial cell and highly specific tight junctions between them, the pericytes which share with the endothelial cells a common capillary basement membrane …

publication date

  • July 6, 2011