Plasma homocysteine after methionine loading in patients with schizophrenia Academic Article uri icon


  • Objective: Although disturbed sleep is a common symptom in schizophrenia, it is often dismissed on the basis that these patients stay up late because most of them are unemployed. In a small number of previous studies abnormalities in sleep onset, sleep maintenance and sleep structure have been reported in patients regardless of either their medication status or the phase of the clinical course. In our naturalistic study, we are investigating the extent to which sleep abnormalities are a genuine problem in schizophrenia and whether abnormalities of the circadian timing system may contribute to the abnormal pattern of sleep often reported in this patient group. Methods: Eighteen medicated, mentally stable outpatients fulfilling DSM-IV criteria for schizophrenia and reporting poor sleep were compared with eighteen age-and gender-matched …

publication date

  • January 1, 2008