198: Exodus 1 (CCL20) is a chemokine involved in spontaneous parturition at term as well as in preterm labor in the presence or absence of infection/inflammation Academic Article uri icon

abstract

  • Objective Exodus 1, also known as CCL20, is a chemokine that participates in chemotaxis of immature dendritic cells, effector/memory T-cells, and B-lymphocyes. mRNA expression for CCL20 has been demonstrated in fetal lung and placenta. We propose that this chemokine is involved in parturition because of its role in the chemotaxis of dendritic cells as well as calcium mobilization. The objective of this study was to determine whether CCL20 can be detected in the amniotic fluid (AF), and if the AF concentration of this chemokine changes with advancing gestational age, labor both term and preterm, and intra-amniotic infection/inflammation (IAI). Study design A cross-sectional study was conducted including the following groups: 1) mid-trimester (n= 65); 2) term not in labor (TNL; n= 22); 3) term in labor (TIL; n= 47); 4) spontaneous PTL with IAI (n= 38); 5) PTL without IAI who delivered …

publication date

  • December 1, 2007