459: Nkp46, nkp44 and nkp30 expression in maternal blood and placenta of patients with spontaneous preterm deliveries Academic Article uri icon

abstract

  • Objective Natural killer (NK) cells are cytotoxic lymphocytes that constitutes a major component of the innate immune system. Decidual NK (dNK) cells play an important physiologic role in pregnancy. NK-expressed natural cytotoxicity receptors (NCRs), NKp30, NKp46 and NKp44, are key NK receptors that could be involved in preterm delivery (PTD). The aim of this study is to investigate whether mRNA expression levels of NKp30, NKp46, and NKp44 from maternal peripheral blood and the decidua can predict PTD Study Design A prospective case-control study was conducted, in which maternal peripheral blood samples and decidua samples were collected from patients with spontaneous PTD (n= 9) as compared with patients delivered at term (above 37 weeks gestation; n= 13). The maternal peripheral blood and placenta samples were analyzed for mRNA expression of NKp30 …

publication date

  • January 1, 2017