Estimated glomerular filtration rate within the normal or mildly impaired range and incident non-valvular atrial fibrillation: Results from a population-based cohort study Academic Article uri icon


  • Background Lower estimated glomerular filtration rate, in particular in the significant renal impairment range (estimated glomerular filtration rate< 60 ml/min/1.73 m2), is associated with incident atrial fibrillation. This association is less established within the normal or mildly impaired estimated glomerular filtration rate range. Methods Using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate formula, we identified ambulatory adults (> 22 years old) without rheumatic heart disease or prosthetic valves and with 60 ml/min/1.73 m2< estimated glomerular filtration rate< 130 ml/min/1.73 m2 in their index visit, for incident, newly-diagnosed atrial fibrillation. We analyzed cohorts with and without prior cardiovascular disease. Results Over a mean follow- up of 104 months and> 10 m patient-years of follow-up (∼ 75%< 60 years old,∼ 57 …

publication date

  • January 1, 2017