498: Placental angiogenic biomarkers in maternal blood improve the prediction of future adverse perinatal outcome in intrauterine growth restriction pregnancies Academic Article uri icon

abstract

  • Objective Placental intrauterine growth restriction (IUGR) is a leading cause of neonatal mortality and morbidity. Earlier study has demonstrated possible benefits of angiogenic biomarkers in maternal blood in identifying women with placental growth restriction pregnancies, as oppose to other IUGR etiologies. In the present study we investigated whether maternal circulating levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase (sFlt)-1 can be used for the prediction of future adverse perinatal outcomes in IUGR pregnancies. Study Design The study included 48 singleton pregnancies diagnosed with IUGR. Doppler velocimetry of the umbilical (Umb) and uterine (UT) arteries was performed. Blood samples were obtained upon diagnosis (gestational age 24-35 weeks). Serum concentrations of PlGF and sFlt-1 were measured by ELISA. Adverse …

publication date

  • January 1, 2018