Neutrophil functions in morbidly obese subjects Academic Article uri icon

abstract

  • The present study aimed to determine different peripheral blood neutrophil functions in 18 morbidly obese subjects with body mass index (BMI) ranging between 35 and 69 kg/m 2 in parallel with age-and gender-matched lean controls. Peripheral blood neutrophil functions of obese subjects and matched lean controls were determined. Neutrophils of obese subjects showed significant elevation of the release of basal superoxides (P< 0· 0001), formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated superoxides (P< 0· 0001) and opsonized zymosan (OZ)-stimulated superoxides (P< 0· 045) compared with lean controls. Interestingly, there were no differences in phorbol myristate acetate (PMA)-stimulated superoxide production by neutrophils of the obese subjects and controls. There was also a significant elevation of chemotactic (P< 0· 0003) and random (P< 0· 0001) migration of …

publication date

  • July 1, 2015