Differential regulation of Th1/Th2 cytokine responses by placental protein 14 Academic Article uri icon


  • Abstract The potency of TCR signaling during primary CD4+ T cell activation influences initial cytokine expression patterns and subsequent polarization toward either Th1 or Th2 subsets. In this study, we demonstrate that the T cell inhibitor placental protein 14 (PP14; glycodelin) preferentially inhibits Th1 cytokine responses and chemokine expression when present during ex vivo priming of CD4+ T cells. PP14 synergizes with exogenously added IL- 4 in skewing T cell responses. Significantly, PP14 impairs the down-regulation of GATA-3 …

publication date

  • November 1, 2004