The recovery from closed head trauma correlates with the decrease of blood Glu levels Academic Article uri icon

abstract

  • Materials and Methods: After approval of the Animal Care Committee, spontaneously breathing 24 male Sprague Dawley rats weighing 200–300 g were anesthetized with 2% isoflurane and a cranial impact of 0.5 J was delivered by a rod. Neurological severity score (NSS) was determined at 1 h and 24 h after CHT. Points are assigned for alterations of motor functions and behavior so that the maximal score of 25 represents severe neurological dysfunction whilst a score of 0 indicates an intact neurological condition. The G was measured using a spectrofluorometric assay (Graham and Aprison). Values are presented as mean±standard deviation. In order to demonstrate that the NSS changes are correlated with the changes of blood G levels, we plotted in Figure the% NSS improvement of individual rats assessed 24 h after TBI versus the% decrease of their blood G levels …

publication date

  • January 1, 2006