Severe hyponatremia induced by theophylline and trimethoprim Academic Article uri icon


  • Hyponatremia is a common adverse effect of many drugs (diuretics, antipsychotic agents, carbamazepine, and others). Among the uncommon causes of hyponatremia are theophylline and trimethoprim. We describe a woman who presented with severe symptomatic hyponatremia following treatment with anhydrous theophylline and developed trimethoprim-induced severe hyponatremia 6 months later.

publication date

  • January 1, 2001