O14. Deep TMS of the Medial Prefrontal and Anterior Cingulate Cortices for OCD: A Double-Blinded Multi-Center Study Academic Article uri icon


  • Background Obsessive compulsive disorder (OCD) is a common disabling disease, yet medications only result in a reduction of symptoms for 40-60% of patients. Symptom severity is correlated to the degree of hyperconnectivity in the cortical-stiriatal-thalamic-cortical circuit and increased glucose metabolism in the anterior cingulate cortex during symptom provocation and at rest. Methods Ninety-four OCD patients were randomized to receive twenty-nine active or sham treatments over six weeks. Deep transcranial magnetic stimulation (dTMS) was applied over the medial prefrontal (mPFC) and anterior cingulate cortices (ACC) using the H7 dTMS coil. Immediately after individualized symptom provocation dTMS was administered at 100% resting motor threshold of the foot, 20HZ pulse frequency, in 2 second trains, with a 20 second inter-train interval totaling 2000 pulses …

publication date

  • January 1, 2018