Synthesis of 1-alkylthio-3H-indolizin-3-ones Academic Article uri icon


  • We have recently tbund that 2-(t-alkylthio-2-cyanoethenyl)pyrroies are tbrmed in the reaction of ethyt pyrrole-2dithiocarboxylates of the I type with malonodinitrile and cyanoacetamide in the KOH--DMSO system with subsequent alkylation [1]. In attempting to extend this reaction to methylene-active compounds II with an ester grouping we observed that the principal (R = CH) or only pathway in this case is the formation of 1-ethylthio-3H-indolizin-3-ones IVa-c.

publication date

  • January 1, 1992