Predictors of health-related Utility weights in a consecutive cohort of real-world Crohn’s disease patients in Israel Academic Article uri icon


  • OBJECTIVES Estimating health-related utility weights in Crohn's Disease (CD) patients is crucial for assessing the cost-effectiveness of new pharmaceutical interventions. However, values used in these analyses are usually based on secondary data and vary substantially among studies. We estimated utility weights in a consecutive sample of real-world CD patients. METHODS Patients enrolled in an ongoing socio-economic study of CD in the Israeli adult patient population completed the self-administered SF-36 questionnaire and were assessed for their current clinical status, including the Harvey-Bradshaw Index (HBI) of disease severity. Patients were classified to one of the four disease states: disease remission (HBI< 5); mild disease (HBI 5-7); moderate disease (HBI 8-16), and severe disease (HBI> 16). For each patient enrolled we calculated a utility weight using the SF …

publication date

  • January 1, 2015