- Objective To describe the first reported case of a seizure in a patient using the dietary supplement DHEA in an attempt to improve ovarian oocyte production. Design Case report. Setting University-affiliated teaching hospital, neurologic department. Patient(s) A 30-year-old woman with fragile X syndrome and no history of any convulsive disorder who was receiving IVF treatment. Intervention(s) Daily treatment with the dietary supplement DHEA. Main Outcome Measure(s) Generalized seizure. Result(s) After 1 month of DHEA treatment, the patient was admitted with a generalized seizure. Conclusion(s) A generalized seizure, associated with concurrent intake of DHEA.