Pediatric Invasive: A Nationwide Prospective Studyhaemophilus influenzae: A Nationwide Prospective Study Infections in Israel in the Era of: A Nationwide Prospecti... Academic Article uri icon


  • Background: The conjugated Haemophilus influenzae (Hi) type b vaccine caused a marked decrease in invasive Hi disease rates. Nonencapsulated Hi infection now constitutes most invasive Hi morbidity and mortality. This study examines invasive Hi infection incidence in Israel in the postvaccine era years, 2003–2012, and characterizes the epidemiology, clinical diagnosis and case fatality rates of invasive Hi disease in children< 15 years of age. Methods: An ongoing, nationwide prospective surveillance program for invasive Hi infections in Israel. Epidemiologic and clinical data were collected. Diagnoses were classified as meningitis, pneumonia, bacteremia/sepsis and other clinical foci. Results: Overall, 389 cases of invasive Hi infections were identified; 242 (62%) nontypable Hi (NTHi), 103 (26%) Hi type b (Hib) and 41 (11%) encapsulated non-b Hi (enbHi). Children< 1 year …

publication date

  • May 1, 2014