Role of a novel HLA-DQA1* 01: 02; DRB1* 15: 01 mixed-isotype heterodimer in the pathogenesis of'humanized'multiple sclerosis-like disease Academic Article uri icon

abstract

  • Background: HLA-DR15-haplotype (DRB1* 15: 01-DQA1* 01: 02-DQB1* 0602-DRB5* 01: 01) association with multiple sclerosis (MS) is conventionally attributed to effects from HLA- DRB1* 15: 01, with impact on MS-risk from the neighboring HLA-DQ locus unclear. Results: Functional studies show MS-like disease dependent on a novel DQA1* 01: 02; DRB1* 15: 01 mixed-isotype-heterodimer.

publication date

  • April 24, 2015