204: Maternal history of recurrent pregnancy loss increases the risk for long-term pediatric respiratory morbidity of the offspring Academic Article uri icon


  • Objective While the etiology in many cases of recurrent pregnancy loss (RPL) is unclear, recent evidence suggests possible immunological dysfunction, which is a common etiology for many pediatric respiratory diseases. We sought to investigate whether maternal history of RPL is associated with long-term respiratory morbidity of the offspring. Study Design A population based cohort analysis was performed comparing the risk of long-term respiratory morbidity (up to the age of 18 years) of children born to mothers with and without a history of RPL (defined as two or more losses). Respiratory morbidity included hospitalizations involving a pre-defined set of ICD-9 codes, as recorded in the hospital medical records. Deliveries occurred between the years 1991-2014 in a tertiary medical center. Multiple pregnancies and fetal congenital malformations were excluded. A Kaplan-Meier survival …

publication date

  • January 1, 2018