61. Persistent blood-brain barrier disruption in humans: a window for neurodegenerative diseases Academic Article uri icon


  • Maintaining a unique extracellular environment in the central nervous system (CNS) is assumed to be crucial for the proper function of its cellular elements. Formed during the late embryonic and early neonatal period the blood-brain barrier (BBB) is an endothelial barrier present in the capillaries throughout the brain, acting as a physical barrier designed to restrict the passage of potential harmful agents into the CNS while retaining the passage of nutrients and waste products to and from the general circulation. It consists of three layers …

publication date

  • January 1, 2004