Signal Transduction Mediated by the T-Cell Antigen Receptor Academic Article uri icon


  • BACKGROUND The function of the T-cell antigen receptor (TCR) is to bind to foreign antigenic peptides, themselves bound to cell-surface proteins encoded by the major histocompatibility complex (MHC).'This binding event, in turn, results in an activation of multiple biochemical pathways, and, ultimately, depending on the setting, leads to the activation, inactivation, or differentiation of the T cell. 293 The receptor consists of multiple proteins encoded by different genes (FIG. 1). The recognition subunits, a and p, in the majority of TCRs, are disulfide-linked immunoglobulin-like molecules each comprised of a variable and constant regi~ n.~ The variable regions are in turn encoded by several genetic elements and together comprise the binding regions for interaction with the peptide-MHC ligand. These chains are associated with several nonpolymorphic molecules, the CD3-y …

publication date

  • January 1, 1995