Expression of HLA class I-encoded cell surface antigens in transitional cell carcinoma of the urinary bladder Academic Article uri icon


  • The major histocompatibility complex (MHC) is one of the most important factors affecting the membrane-associated molecules which play a piv- otal role in the interaction of a cell with its humoral and cellular microenvironment (1). The activity of cytotoxic T cells is, in fact, MHC class I antigen- restricted (2). In many different mouse tumors, a deviant and unbalanced expression of glyco- proteins encoded by different loci of the MHC has been described (1). Also in several human tumors a reduced expression of class I antigens has been reported (3-6). Since MHC glycoproteins are of importance in regulation of target cell recognition and elimination by both specific and non-specific killer cells, it was the aim of this study to investigate the expression of MHC class I molecules on normal bladder cells and on malignant cells of patients with transitional cell carcinoma (TCC) of the bladder. Forty-two biopsies were obtained from patients with …

publication date

  • January 1, 1992