PICOT-HD: a highly conserved protein domain that is often associated with thioredoxin and glutaredoxin modules Academic Article uri icon


  • Multiple alignment of PICOT-HD sequences. Sequences were obtained by searches of protein sequence databases using the PICOT-HD1 of human PICOT as query and protein alignment using MultAlin 9 x Multiple sequence alignment with hierarchical clustering. Corpet, F. Nucleic Acids Res. 1988; 16: 10881–10890Crossref| PubMed| Scopus (3282) See all References 9 multiple sequence alignment program (http://www. toulouse. inra. fr/multalin. html) and manual adjustment. Deletion and insertion positions are denoted by dashes. The consensus (shown below the alignment) includes residues conserved in the majority (> 90%, upper case in red;> 50%, lower case in blue) of the aligned sequences. Residues are considered similar for this purpose if they fall into one of the following four groups:!=(I, V); $=(L, M);%=(F, Y);#=(N, D, Q, E). Predicted secondary-structure elements …

publication date

  • January 1, 2000