Porphyrin binding and aggregation Academic Article uri icon

abstract

  • High potency, in terms of photodynamic activity at the tumor site, is a major demand for the successful use of porphyrins in photodynamic therapy (PDT). Yet there are additional issues which will affect the outcome of the treatment. These stem from events in which the administered porphyrin will engage, in vivo, en route from the site of drug administration to the site of drug action. These include self-aggregation," binding to serum pro-teins,” and association with membranes.******* The overall outcome of these events will be a major …

publication date

  • June 21, 1990