The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Academic Article uri icon


  • Abstract Objective To determine if statin therapy reduces the incidence of severe sepsis and the levels of inflammatory cytokines in patients with acute bacterial infection. Design Double- blind placebo controlled randomized clinical trial. Setting Department of medicine and medical intensive care unit in a tertiary university medical center. Patients and participants A total of 83 patients with suspected or documented bacterial infection were enrolled. We randomly assigned 42 patients to receive 40 mg of simvastatin orally, followed by 20 mg …

publication date

  • January 1, 2009