- An alarming increase in the use/abuse of synthetic psychoactive substances known as “designer drugs” or “legal highs” (“Nice Guy” in Israel) has caused the governments of many countries including the USA to pass legislation banning the sale, possession, and use of specific synthetic cathinones and cannabinoids. “New psychoactive substances” (NPS) pose a public health risk. Early research on synthetic cannabinoids done in the 1980s and 1990s describes benign outcomes. Research in vivo in animals supported the positive influence of synthetic cannabinoids as an antiemetic used to prevent vomiting and nausea. However, reports of emergency departments evidence the toxicity and side effects of synthetic cannabinoids. This situation calls for policy, law enforcement, and medical intervention to address this growing problem.