Highlights from Recent Cancer Literature Academic Article uri icon

abstract

  • We all know by now that cancers are not just masses of malignant cells but instead complex “rogue organs” with many different cell types that are attracted to, and corrupted by, the transformed cells. Some of the cell-attracting signals act locally, but recently attention has turned to endocrine signals sent by cancers that mobilize cells from the bone marrow. Elkabets and colleagues build upon initial descriptions of “instigator” tumors that can mobilize bone marrow cells into the circulation. Once mobilized, these bone marrow cells are also able to promote the growth of distant “responder” tumors that are usually indolent unless growing in a mouse that also has an instigator tumor. These bone marrow cells are able to promote tumor growth. The myofibroblast-rich reactive stroma that develop have now been identified as Sca þ cKit À hematopoietic progenitor cells, and the gene that was …

publication date

  • March 1, 2011