Intermuscular adipose tissue and thigh muscle area dynamics during an 18-month randomized weight loss trial Academic Article uri icon


  • It remains unclear whether intermuscular adipose tissue (IMAT) has any metabolic influence or whether it is merely a marker of abnormalities, as well as what are the effects of specific lifestyle strategies for weight loss on the dynamics of both IMAT and thigh muscle area (TMA). We followed the trajectory of IMAT and TMA during 18-mo lifestyle intervention among 278 sedentary participants with abdominal obesity, using magnetic resonance imaging. We measured the resting metabolic rate (RMR) by an indirect calorimeter. Among 273 eligible participants (47.8±9.3 yr of age), the mean IMAT was 9.6±4.6 cm2. Baseline IMAT levels were directly correlated with waist circumference, abdominal subdepots, C- reactive protein, and leptin and inversely correlated with baseline TMA and creatinine (P< 0.05 for all). After 18 mo (86.3% adherence), both IMAT (− 1.6%) and TMA (− 3.3%) …

publication date

  • January 1, 2016